Posttransplantation anemia in kidney transplant recipients
نویسندگان
چکیده
We sought to assess the frequency and predictors of early and late posttransplantation anemia (PTA). In addition, we aimed to assess the outcomes of patients with anemia and to assess the impact of anemia on mortality, graft function, and graft failure.Patients who underwent kidney transplantation in a single center during a 4-year period were included. Predictors associated with the development of anemia at 6 months (early PTA) or 2 years (late PTA) were evaluated in a univariate and multivariate analyses. The effects of anemia and other variables on mortality and graft function were assessed.A total of 266 kidney transplant recipients were included. The prevalence of PTA at 6 months (early PTA) was 51.3% and at 2 years (late PTA) was 36.6%. Female sex was significantly associated with early PTA. Patients with early PTA proceeded to late PTA. Patients with both early and late PTA had a higher mortality rate at 4 years compared to patients without anemia. On multivariable analysis, lower Hb at 2 years posttransplantation (hazard ratio [HR] 0.716, 95% confidence intervals [CI] 0.541-0.948, for every increment of 1 g/dL) was significantly associated with mortality. Patients with late PTA suffered a decline in eGFR compared to patients without anemia (P = .026). Furthermore, a lower Hb at 2 years posttransplantation was also associated with graft failure (HR 0.775, 95% CI 0.619-0.969, for every increment of 1 g/dL).Post-transplantation anemia is significantly associated with late mortality, with a decline in graft function and with an increased incidence of graft failure.
منابع مشابه
Posttransplantation anemia: mechanisms and management.
Treatment of anemia in patients with chronic kidney disease is a topic of increasing interest and controversy. However, anemia in the kidney transplant recipient has received relatively little attention in the literature despite the reported high prevalence of 30% to 40%. The pathogenesis of anemia among kidney transplant recipients is usually multifactorial, including compromised graft functio...
متن کاملImpact of anemia after renal transplantation on patient and graft survival and on rate of acute rejection.
BACKGROUND AND OBJECTIVES The impact of posttransplantation anemia on patient survival, renal allograft survival, and rate of acute rejection is not known. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A total of 1023 patients who underwent kidney transplantation at one center from January 1992 through June 2003 were retrospectively analyzed. Posttransplantation anemia was defined as mean hem...
متن کاملIntroduction to the well-transplant visit--more than vital signs and a creatinine check.
Against the backdrop of remarkable advances in renal transplantation in the past half-century resulting in excellent early patient and allograft survival rates, it is clear that commensurate improvement in long-term outcomes lags. Current research is increasingly focused on improving the longevity and quality of life after transplantation. As prognostic risk factors are identified, new strategi...
متن کاملPretransplant physical functioning and kidney patients' risk for posttransplantation hospitalization/death: evidence from a national cohort.
Patient physical functioning level is an indicator of medical fitness that may predict outcomes after kidney transplantation. A small study of patients at a single center found a correlation between patient-rated physical functioning pretransplantation and the number of emergency hospital visits posttransplantation. In a national multicenter cohort, the association of incident dialysis patients...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 96 شماره
صفحات -
تاریخ انتشار 2017